6-Methyl-5-nitropyrimidine-2,4(1H,3H)-dione(CAS: 16632-21-6)

6-Methyl-5-nitropyrimidine-2,4(1H,3H)-dione (CAS: 16632-21-6) is a solid with a crystalline form. Its molecular weight is approximately 222.11 g/mol. It has low water solubility but is soluble in common organic solvents like methanol and ethanol. This compound is known for its reactivity, particularly towards nucleophilic substitution reactions and its ability to form complexes with metals.

6-Methyl-5-nitropyrimidine-2,4(1H,3H)-dione can be synthesized via a multi-step process starting with the nitration of pyrimidine derivatives. Commonly, the nitration is performed using nitric acid in the presence of sulfuric acid as a catalyst. The final step involves the addition of methyl groups using methanol and an acid catalyst. The overall reaction is highly selective and yields up to 90% of the desired product.

6-Methyl-5-nitropyrimidine-2,4(1H,3H)-dione (CAS: 16632-21-6) is primarily used in the pharmaceutical industry for the synthesis of various medicinal compounds. It is also utilized in the development of sensors for detecting specific chemicals and in the production of certain types of polymers. Additionally, it plays a role in semiconductor manufacturing due to its unique electronic properties.

When handling 6-Methyl-5-nitropyrimidine-2,4(1H,3H)-dione (CAS: 16632-21-6), it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. This compound should be stored in a cool, dry place away from direct sunlight and sources of ignition. Always use a fume hood during handling to minimize inhalation risks. In case of a spill, immediately clean it up using appropriate chemical spill kits and refer to the Safety Data Sheet (SDS) for further guidance.