Ethyl 4,6-dichloro-2-methylnicotinate(CAS: 686279-09-4)

Ethyl 4,6-dichloro-2-methylnicotinate is a crystalline compound with a molecular weight of approximately 247.01 g/mol. It has a solubility of about 1.5 g/L in water. Chemically, it shows moderate reactivity, particularly in acidic conditions. It is used in pharmaceutical applications and may require protection from light and moisture during storage.

Ethyl 4,6-dichloro-2-methylnicotinate is typically synthesized via the condensation of 4,6-dichloro-2-methylpyridine with acetyl chloride in the presence of anhydrous aluminum chloride as a catalyst. The reaction yields a mixture of isomers, but the desired one can be isolated through recrystallization. The reaction is exothermic and requires careful temperature control.

Ethyl 4,6-dichloro-2-methylnicotinate is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It can also be found in the polymer industry for the modification of polymer properties and in the chemical sensing sector for developing gas sensors. Its use in semiconductors is less common but it can be utilized in specific applications.

Handling Ethyl 4,6-dichloro-2-methylnicotinate should be done with caution. It is recommended to use personal protective equipment (PPE) such as gloves and goggles. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using an appropriate solvent and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.