4-(4H-1,2,4-triazol-4-yl)benzoic acid(CAS: 157069-48-2)

4-(4H-1,2,4-triazol-4-yl)benzoic acid (CAS: 157069-48-2) is a white crystalline solid with a molecular weight of 223.20 g/mol. It is slightly soluble in water and has a pKa of 4.6. This compound is reactive towards bases and can form stable salts. It is also soluble in various organic solvents like ethanol and acetone.

4-(4H-1,2,4-triazol-4-yl)benzoic acid is usually synthesized via the condensation of 4-amino-benzoic acid with 1,2,4-triazole. The reaction is typically performed in an aqueous medium at room temperature with a yield of around 70-80%. This process does not require specific catalysts but can be optimized for better selectivity and yield with temperature and solvent adjustments.

4-(4H-1,2,4-triazol-4-yl)benzoic acid (CAS: 157069-48-2) is used in the pharmaceutical industry for the synthesis of various drug candidates. It also finds applications in the polymer industry for the modification of polymer properties and in the development of sensors and semiconductors for their improved performance and stability.

Proper personal protective equipment (PPE) should be worn when handling 4-(4H-1,2,4-triazol-4-yl)benzoic acid (CAS: 157069-48-2). This includes gloves, goggles, and a lab coat. Work should be conducted in a fume hood to avoid inhalation. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.