1-(2-Fluoro-5-nitrophenyl)ethanone(CAS: 79110-05-7)

1-(2-Fluoro-5-nitrophenyl)ethanone is a white or off-white crystalline solid with a molecular weight of approximately 214.07 g/mol. It has a solubility of about 7.4 g/L in water at 20°C and is moderately soluble in organic solvents like ethanol and acetone. Chemically, it is a ketone with a high reactivity towards nucleophiles and reducing agents. It undergoes nitro group reduction and fluoro substitution under appropriate conditions.

1-(2-Fluoro-5-nitrophenyl)ethanone can be synthesized through the reaction of 2-fluoro-5-nitrobenzaldehyde with an appropriate acylating agent such as acetyl chloride in the presence of a base like pyridine. The yield is typically around 70-80%, and the reaction is carried out in an inert atmosphere to prevent oxidation and side reactions.

1-(2-Fluoro-5-nitrophenyl)ethanone is used in the pharmaceutical and chemical industries for the synthesis of intermediates and active pharmaceutical ingredients. It also finds applications in the development of sensors and materials for electronic devices due to its functional groups that can participate in various chemical reactions.

When handling 1-(2-Fluoro-5-nitrophenyl)ethanone, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store it in a cool, dry place, away from direct sunlight and heat sources. Use a fume hood during handling, and follow standard laboratory safety protocols. In case of a spill, neutralize it with an appropriate chemical neutralizer and dispose of it according to local regulations. Always refer to the safety data sheet (SDS) for detailed information on handling procedures.