(2E)-3-(4-Fluorophenyl)acrylic acid(CAS: 459-32-5)

(2E)-3-(4-Fluorophenyl)acrylic acid (CAS: 459-32-5) is a colorless or white crystalline solid with a molecular weight of approximately 182.14 g/mol. It has a melting point of 50-52°C and a solubility of about 0.15 g/100 mL in water. It is reactive under basic conditions and is susceptible to hydrolysis. This compound is insoluble in common organic solvents like ethanol and acetone but soluble in polar solvents like dimethylformamide.

(2E)-3-(4-Fluorophenyl)acrylic acid (CAS: 459-32-5) is typically synthesized via a two-step process. First, 4-fluorophenylacetonitrile is treated with an acid catalyst like sulfuric acid to form the nitrile acid. Then, the nitrile acid is reduced to the acid using a reductive amination process with hydrazine or a similar reducing agent. The overall reaction is selective and yields up to 90% of the desired product.

(2E)-3-(4-Fluorophenyl)acrylic acid (CAS: 459-32-5) is used in various industries, particularly in pharmaceuticals for the synthesis of drug intermediates, and in the production of polymer additives. It is also utilized in the manufacturing of sensors and semiconductors due to its electronic properties.

When handling (2E)-3-(4-Fluorophenyl)acrylic acid (CAS: 459-32-5), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Handle the compound in a well-ventilated area or a fume hood to avoid inhalation of fumes. Spills should be cleaned up with appropriate chemicals and discarded according to local regulations. Refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.