4-Bromo-2-fluorobenzonitrile(CAS: 105942-08-3)

4-Bromo-2-fluorobenzonitrile (CAS: 105942-08-3) is a crystalline solid with a molecular weight of approximately 224.03 g/mol. It has a low solubility in water but is soluble in organic solvents such as acetone, diethyl ether, and dimethylformamide. The compound is highly reactive, particularly in halogenation and nucleophilic substitution reactions.

4-Bromo-2-fluorobenzonitrile (CAS: 105942-08-3) is commonly synthesized via a multi-step process, starting with 2-fluorobenzoic acid. The acid is nitrated to form 2-fluorobenzonitrile, which is then brominated. This synthesis often involves the use of concentrated sulfuric acid for nitration and N-bromosuccinimide for bromination, with high selectivity and good yields.

4-Bromo-2-fluorobenzonitrile (CAS: 105942-08-3) is used in various industries, including pharmaceuticals and fine chemicals, where it serves as an intermediate in the synthesis of complex organic compounds. It is also utilized in the development of sensors and semiconductors due to its unique chemical reactivity and functional groups.

When handling 4-Bromo-2-fluorobenzonitrile (CAS: 105942-08-3), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up according to standard procedures, and the material safety data sheet (MSDS) should be consulted for specific guidelines. Ensure proper storage and disposal to comply with environmental regulations.