3-[2-(Trifluoromethyl)phenyl]acrylic acid(CAS: 2062-25-1)

3-[2-(Trifluoromethyl)phenyl]acrylic acid (CAS: 2062-25-1) is a white to off-white crystalline solid. Its molecular weight is approximately 249.12 g/mol. This compound is poorly soluble in water but soluble in organic solvents like ethanol and acetonitrile. It is moderately reactive, particularly under basic conditions, and can undergo esterification and amidation reactions. It is stable under typical laboratory conditions but should be stored in a cool, dry place away from direct sunlight.

3-[2-(Trifluoromethyl)phenyl]acrylic acid is typically synthesized via the reaction of 2-(trifluoromethyl)phenylacetyl chloride with sodium hydroxide in a polar aprotic solvent like dimethylformamide (DMF). The process involves the nucleophilic attack of the hydroxide ion on the acetyl chloride group, followed by dehydration to form the carboxylic acid. Common catalysts include triethylamine and 4-dimethylaminopyridine (DMAP) to improve selectivity and yield.

3-[2-(Trifluoromethyl)phenyl]acrylic acid finds applications in various industries. It is used in the pharmaceutical sector for the synthesis of certain drugs and intermediates. In the polymer industry, it serves as a monomer for the production of speciality polymers. Additionally, it is utilized in the development of sensors and semiconductors due to its unique physicochemical properties.

When handling 3-[2-(Trifluoromethyl)phenyl]acrylic acid (CAS: 2062-25-1), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood to avoid inhalation of its fumes. Spills should be cleaned up using absorbent materials, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed information on handling procedures and emergency response.