Compound Q&A
How is 3-[2-(Trifluoromethyl)phenyl]acrylic acid (CAS: 2062-25-1) typically synthesized?
Answer
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3-[2-(Trifluoromethyl)phenyl]acrylic acid is typically synthesized via the reaction of 2-(trifluoromethyl)phenylacetyl chloride with sodium hydroxide in a polar aprotic solvent like dimethylformamide (DMF). The process involves the nucleophilic attack of the hydroxide ion on the acetyl chloride group, followed by dehydration to form the carboxylic acid. Common catalysts include triethylamine and 4-dimethylaminopyridine (DMAP) to improve selectivity and yield.
About
CAS No
2062-25-1
English Name
3-[2-(Trifluoromethyl)phenyl]acrylic acid
Molecular Formula
C10H7F3O2
Molecular Weight
216.16 g/mol
SMILES
C1=CC=C(C(=C1)C=CC(=O)O)C(F)(F)F
InChIKey
AMVYAIXPAGBXOM-UHFFFAOYSA-N
Last Updated: 2025-09-16 13:49
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