3-(Methylsulfonyl)benzaldehyde(CAS: 43114-43-8)

3-(Methylsulfonyl)benzaldehyde is a colorless to light yellow liquid with a molecular weight of 214.24 g/mol. It has a pKa of approximately 8.1 and is slightly soluble in water but soluble in organic solvents such as ethanol and acetone. It is highly reactive, especially under acidic conditions, and can undergo nucleophilic substitution reactions.

3-(Methylsulfonyl)benzaldehyde can be synthesized by the reaction of methyl methanesulfonate with benzaldehyde in an aqueous medium. Commonly, the reaction is carried out in the presence of a base such as sodium hydroxide to ensure good yield. The product can be purified by recrystallization from ethanol or other suitable solvents.

3-(Methylsulfonyl)benzaldehyde is used in the pharmaceutical industry as a precursor for the synthesis of certain drugs. It also finds applications in the polymer industry as a monomer, in the production of electronic materials as a semiconductor precursor, and in the development of new sensor technologies.

When handling 3-(Methylsulfonyl)benzaldehyde, it is essential to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or under a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be ventilated thoroughly. Always consult the Safety Data Sheet (SDS) for detailed handling and storage instructions.