N-[(1R)-1-(Dihydroxyboryl)-3-methylbutyl]-Nalpha-(2-pyrazinylcarbonyl)-L-phenylalaninamide

Basic Information

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CAS Number

179324-69-7

Molecular Formula

C19H25BN4O4

Molecular Weight

384.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Physical State

Powder

Melting Point

139-143°C

Boiling Point

684.30° C

Solubility

Soluble in chloroform, dimethyl sulfoxide, ethanol and methanol.

Refractive Index

1.56

SMILES

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B([C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c2cnccn2)(O)O

InChI

InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1

InChIKey

GXJABQQUPOEUTA-RDJZCZTQSA-N

LogP

0.36059999999999875

Topological Polar Surface Area

124.44000000000001 Å²

Hydrogen Bond Donor/Acceptor

4 / 8

Complexity

500

Safety Information

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Hazard Statement

H300 Fatal if swallowed
Acute toxicity, oral

H310 Fatal in contact with skin
Acute toxicity, dermal

H330 Fatal if inhaled
Acute toxicity, inhalation

H372 Causes damage to organs through prolonged or repeated exposure
Specific target organ toxicity, repeated exposure

Hazard Class

Class 6.1 Class 6.1

Stability

Hygroscopic and Moisture Sensitive

Synonyms & References

English

Bortezomib
MG-341
PS-341
[(1r)-3-methyl-1-[[(2s)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-boronic acid
dpba
VELCADE
VELCADE(BORTEZOMIB)
Boronic acid, B-[(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]-
Bortezomib for research
Bortezomib (PS-341)
((R)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid
bortezomib（Velcade®, Bortecad®, PS-341,MG-341）
Bortizomib
&nbsp
Bortezmib
Bortezomib Base
MG-341 PS-341
PS341
Radiciol
MLM341
BortezoMib R
BortezoMib-D8
MG-341 PS-341
Ps 341
N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE
Bortezomib (Velcade)
[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid
[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
Peptide boronate
69G8BD63PP
Boronic acid, B-[(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl

MDL Number

MFCD09056737

Customs Code

2934999090

FAQ

What is N-[(1R)-1-(Dihydroxyboryl)-3-methylbutyl]-Nalpha-(2-pyrazinylcarbonyl)-L-phenylalaninamide (CAS: 179324-69-7)?

N-[(1R)-1-(Dihydroxyboryl)-3-methylbutyl]-Nalpha-(2-pyrazinylcarbonyl)-L-phenylalaninamide (CAS: 179324-69-7) is a synthetic organic compound belonging to the class of amino acid derivatives. It contains a phenylalanine backbone with a modified side chain featuring a dihydroxyboryl group and a pyrazinylcarbonyl group. This compound is known for its potential applications in pharmaceutical and biochemical research due to its unique functional groups and structural complexity.

What are the main uses of N-[(1R)-1-(Dihydroxyboryl)-3-methylbutyl]-Nalpha-(2-pyrazinylcarbonyl)-L-phenylalaninamide (CAS: 179324-69-7)?

The main uses of N-[(1R)-1-(Dihydroxyboryl)-3-methylbutyl]-Nalpha-(2-pyrazinylcarbonyl)-L-phenylalaninamide (CAS: 179324-69-7) include pharmaceutical research, particularly in the development of drug candidates with enhanced bioavailability and metabolic stability. It may also be used in biochemical studies and as a building block for synthesizing more complex molecules in laboratory settings.

Is N-[(1R)-1-(Dihydroxyboryl)-3-methylbutyl]-Nalpha-(2-pyrazinylcarbonyl)-L-phenylalaninamide (CAS: 179324-69-7) safe?

N-[(1R)-1-(Dihydroxyboryl)-3-methylbutyl]-Nalpha-(2-pyrazinylcarbonyl)-L-phenylalaninamide (CAS: 179324-69-7) is generally considered safe when handled properly. However, it should be treated with care as it may pose risks if inhaled, ingested, or come into contact with skin. Safety data sheets (SDS) should be consulted, and appropriate personal protective equipment (PPE) such as gloves and goggles is recommended during handling.

How should N-[(1R)-1-(Dihydroxyboryl)-3-methylbutyl]-Nalpha-(2-pyrazinylcarbonyl)-L-phenylalaninamide (CAS: 179324-69-7) be stored?

N-[(1R)-1-(Dihydroxyboryl)-3-methylbutyl]-Nalpha-(2-pyrazinylcarbonyl)-L-phenylalaninamide (CAS: 179324-69-7) should be stored in a cool, dry, and dark place, away from moisture and light. It is recommended to keep it in a sealed container, preferably made of glass or high-density polyethylene (HDPE), at a temperature below 25°C. Avoid exposure to air and ensure proper ventilation to maintain stability and prevent degradation.