2-Chloro-6-fluorobenzoyl chloride(CAS: 79455-63-3)

2-Chloro-6-fluorobenzoyl chloride is a white or off-white crystalline solid with a molecular weight of 216.01 g/mol. It has a low solubility in water but is soluble in organic solvents like dichloromethane and acetonitrile. The compound is highly reactive, particularly towards nucleophiles, and can undergo substitution reactions.

2-Chloro-6-fluorobenzoyl chloride is typically synthesized by the condensation of 2-chloro-6-fluorobenzamide with phosgene in the presence of a catalyst like N,N-dimethylformamide (DMF). The reaction yields a single product with good selectivity and moderate to high yield, depending on the conditions.

2-Chloro-6-fluorobenzoyl chloride is used in various industries, including pharmaceuticals for the synthesis of intermediates, polymers for functional materials, and sensors for detection purposes. It is also utilized in the development of semiconductors due to its reactivity and functional groups.

When handling 2-Chloro-6-fluorobenzoyl chloride, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The substance should be handled in a well-ventilated area or a fume hood due to its reactivity. Spills should be handled according to the safety data sheet (SDS) and should be neutralized with an appropriate reagent before disposal.