4-(1-Piperazinyl)-1H-indole dihydrochloride(CAS: 255714-24-0)

4-(1-Piperazinyl)-1H-indole dihydrochloride is a crystalline white powder with a molecular weight of approximately 355.75 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and dichloromethane. It is slightly basic due to the presence of the chloride salt. This compound is thermally stable but may react with strong bases or oxidizing agents.

4-(1-Piperazinyl)-1H-indole dihydrochloride is typically synthesized by the reaction of 4-hydroxyindole with piperazine in the presence of an acid catalyst such as hydrochloric acid. The reaction is carried out at room temperature, and the product is isolated by recrystallization from an appropriate solvent. The yield is moderate, and the purity is high.

4-(1-Piperazinyl)-1H-indole dihydrochloride is primarily used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It is also used in the chemical industry for the development of new materials and in the sensing technology sector for the fabrication of gas sensors.

When handling 4-(1-Piperazinyl)-1H-indole dihydrochloride, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be performed in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up carefully using appropriate chemicals and procedures. Always refer to the Safety Data Sheet (SDS) for detailed safety information.