Photo-crosslinked integrated triphasic scaffolds with gradient composition and strength for osteochondral regeneration
Literature Information
Hui Li, Ping Song, Yanbo Guo, Di Luo
Owing to the avascular and aneural nature of cartilage tissue and the complex, multilayered structure of osteochondral units, the repair of osteochondral defects poses significant challenges. Traditional monophasic scaffolds have difficulty meeting the repair requirements of both cartilage and bone tissues, whereas multiphasic scaffolds face the issue of interfacial integration. In this study, a triphasic methylpropenylated gelatin (GELMA) hydrogel scaffold was employed to repair osteochondral defects, in which three layers of hydrogel were covalently bonded through a sequential curing process. The upper layer of the scaffold was covalently bonded with chondroitin sulfate, promoting chondrogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). The middle and lower layers of the hydrogel introduced a gradient content of hydroxyapatite, forming a scaffold with gradient mechanical strength and effectively enhancing its angiogenic and osteogenic induction capabilities. Finally, the triphasic integrated scaffold cartilage and bone repair performance was evaluated using a rabbit knee joint defect model. The results demonstrated that the scaffold facilitated accelerated regeneration of osteochondral defects, thus providing a novel strategy for the treatment of osteochondral defects.
Recommended Journals

Pure and Applied Chemistry

Kinetics and Catalysis

Organic Preparations and Procedures International

Journal of Physics and Chemistry of Solids

Science

Proceedings of the National Academy of Sciences of the United States of America

Journal of Heterocyclic Chemistry

European Journal of Wood and Wood Products

Helvetica Chimica Acta

Planta Medica
Related Literature
Synthesis of microporous polymers by Friedel–Crafts reaction of 1-bromoadamantane with aromatic compounds and their surface modification
Ho Lim, Min Chul Cha, Ji Young Chang
DOI: 10.1039/C2PY00511E
Hyperbranched glycoconjugated polymer from natural small molecule kanamycin as a safe and efficient gene vector
Jieli Wu, Linzhu Zhou, Chengyu Jin, Chunlai Tu, Bangshang Zhu, Qi Zhu, Deyue Yan
DOI: 10.1039/C1PY00333J
Polypeptide core–shell silicananoparticles with high grafting density by N-carboxyanhydride (NCA) ring opening polymerization as responsive materials and for bioconjugation
Tushar Borase, Marcello Iacono, Syed I. Ali, Paul D. Thornton
DOI: 10.1039/C2PY00610C
Controlled synthesis of radiolabelled amine methacrylate water-soluble polymers with end-groups of varying hydrophobicity and studies of adsorption behaviour
Mark Long, David W. Thornthwaite, Suzanne H. Rogers, Francis R. Livens, Steve P. Rannard
DOI: 10.1039/C1PY00397F
Facile synthesis of novel poly(α-aminonitrile) networks through one-pot Strecker reactions
Jiacheng Wang, Yoichi Masui, Makoto Onaka
DOI: 10.1039/C2PY00002D
An improved grafting technique for producing imprinted thin film composite beads
Mahadeo R. Halhalli, Carla S. A. Aureliano, Eric Schillinger, Claudia Sulitzky, M. Magdalena Titirici, Börje Sellergren
DOI: 10.1039/C2PY00544A
You might also like
What industries use 4-(4-tert-Butylphenyl)-1H-pyrazol-3-amine (CAS: 1015845-73-4)?
4-(4-tert-Butylphenyl)-1H-pyrazol-3-amine finds applications in various industri...
What industries use H3TATAB (CAS: 63557-10-8)?
H3TATAB is used in the pharmaceutical industry for the synthesis of certain orga...
What are the main uses of 1-Ethyl-3-fluorobenzene (CAS: 696-39-9)?
1-Ethyl-3-fluorobenzene (CAS: 696-39-9) is primarily used as a precursor in the ...
What are the main uses of 1-(tert-Butoxycarbonyl)-4-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid (CAS: 851484-94-1)?
1-(tert-Butoxycarbonyl)-4-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid is prim...
What are the physical and chemical properties of 1-Cyclobutyl-4-piperidinone (CAS: 359880-05-0)?
1-Cyclobutyl-4-piperidinone (CAS: 359880-05-0) is a colorless or white crystalli...
What is Pyridine-2,6-dicarboxylic acid mono-tert-butyl ester (CAS: 575433-76-0)?
Pyridine-2,6-dicarboxylic acid mono-tert-butyl ester (CAS: 575433-76-0) is a che...
What is the market or research trend for 2,3-Difluorophenylalanine (CAS: 236754-62-4)?
The market for 2,3-Difluorophenylalanine (CAS: 236754-62-4) is growing with incr...
How is (2-Hydroxy-1-naphthyl)boronic acid (CAS: 898257-48-2) typically synthesized?
(2-Hydroxy-1-naphthyl)boronic acid can be synthesized through the reduction of 2...
What are the physical and chemical properties of tert-Butyl (5-bromo-6-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate (CAS: 1315351-28-0)?
This compound is a crystalline solid with a molecular weight of approximately 52...
Are there alternatives to 5,7-Dihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)-4H-chromen-3-yl beta-D-glucopyranoside (CAS: 19833-12-6) in synthesis?
While 5,7-Dihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)-4H-chromen-3-yl beta-D-gluc...
Source Journal
Journal of Materials Chemistry B

Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. The journals have a strong history of publishing quality reports of interest to interdisciplinary communities and providing an efficient and rigorous service through peer review and publication. The journals are led by an international team of Editors-in-Chief and Associate Editors who are all active researchers in their fields. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C. More than one Journal of Materials Chemistry journal may be suitable for certain fields and researchers are encouraged to submit their paper to the journal that they feel best fits for their particular article. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive. Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices image block All articles published in Journal of Materials Chemistry B from 2019 onwards will be indexed in MEDLINE®. Articles that primarily focus on providing insight into the underlying science and performance of biomaterials within a biological environment are more suited to our companion journal, Biomaterials Science.
![4-[2-(3,4-Dihydro-2H-chromen-6-yl)-1,3-oxazol-5-yl]-1-(3-{[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl}benzyl)pyridinium bromide structure 4-[2-(3,4-Dihydro-2H-chromen-6-yl)-1,3-oxazol-5-yl]-1-(3-{[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl}benzyl)pyridinium bromide structure](https://static.chemtradehub.com/structs/155/155863-03-9-8183.webp)
![6-[2-(Trifluoromethoxy)phenyl]-2-pyridinecarboxylic acid structure 6-[2-(Trifluoromethoxy)phenyl]-2-pyridinecarboxylic acid structure](https://static.chemtradehub.com/structs/887/887983-48-4-f6ac.webp)


