New cationic linear N-chloramines based on N-t-butylamide: chemical synthesis and antibacterial application

Literature Information

Publication Date 2023-12-18
DOI 10.1039/D3NJ04005D
Impact Factor 3.591
Authors

Lingdong Li, Songwei Zhang, Zhongtian Du, Hande Wang, Hao Zhou


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Abstract

For the first time, we synthesized three types of cationic linear N-chloramines that do not use the popular 5,5-dimethyl hydantoin scaffold. The characterized N-chloramines displayed satisfactory bactericidal activity, and the long-chain analogues exerted greatly elevated biocidal efficacy due to “synergistic” antibacterial actions between the N–Cl moiety and long chain cationic center. Our study provides highly efficacious biocides as well as paving the way for producing novel N-chloramines that exclude toxic cyanide salts.

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New Journal of Chemistry

New Journal of Chemistry
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NJC (New Journal of Chemistry) is a broad-based primary journal encompassing all branches of chemistry and its sub-disciplines. It contains full research articles, communications, perspectives and focus articles. This well-established journal, owned by the Centre National de la Recherche Scientifique (CNRS) of France, has been co-published with the Royal Society of Chemistry since January 1998. NJC is the forum for the publication of high-quality, original and significant work that opens new directions in chemistry or other scientific disciplines. In addition to having a significant chemical component, work published in NJC must demonstrate that it will have an impact on areas of research other than that of the reported work.

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