Dynamic monitoring of an enzymatically driven dissipative toehold-mediated strand displacement reaction

Literature Information

Publication Date 2023-12-06
DOI 10.1039/D3CC05061K
Impact Factor 6.222
Authors

Shuang Li, Disong Zhao, Fangfang Yang, Shufeng Liu


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Abstract

A general strategy to program self-resettable and dissipative toehold-mediated strand displacement reactions was proposed, using DNA strands as the fuel and lambda exonuclease as the fuel-consuming unit. This non-equilibrium system is reversible and temporally controllable. Furthermore, it can be well integrated into a DNA network to temporally control its cascade reaction or dynamic behaviour.

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