Redox-active ligand promoted electrophile addition at cobalt

Literature Information

Publication Date 2023-11-17
DOI 10.1039/D3CC04869A
Impact Factor 6.222
Authors

Minzhu Zou, Kate M. Waldie


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Abstract

The reactivity of an electron-rich cobalt complex bearing an o-phenylenediamide ligand with electrophilic CF3+ and F+ sources is reported. These reactions lead to generation of a Co(III)–CF3 or Co(III)–F complex, promoted by redox-active ligand-to-substrate two-electron transfer. The rate of trifluoromethyl addition at cobalt correlates with the potential difference between the cobalt complex and the CF3+ source. We present initial demonstrations of radical trifluoromethylation and nucleophilic fluorination of organic substrates, setting the stage for the development of electrocatalytic pathways for these bond-forming reactions.

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