Redox-active ligand promoted electrophile addition at cobalt
Literature Information
Minzhu Zou, Kate M. Waldie
The reactivity of an electron-rich cobalt complex bearing an o-phenylenediamide ligand with electrophilic CF3+ and F+ sources is reported. These reactions lead to generation of a Co(III)–CF3 or Co(III)–F complex, promoted by redox-active ligand-to-substrate two-electron transfer. The rate of trifluoromethyl addition at cobalt correlates with the potential difference between the cobalt complex and the CF3+ source. We present initial demonstrations of radical trifluoromethylation and nucleophilic fluorination of organic substrates, setting the stage for the development of electrocatalytic pathways for these bond-forming reactions.
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