A new dual functional H2S donor for fluorescence imaging and anti-inflammatory application

Literature Information

Publication Date 2023-10-24
DOI 10.1039/D3CC03881E
Impact Factor 6.222
Authors

Shumei Huang, Zejun Li, Wenhui You, Guansheng Zheng, Huatang Zhang, Yin Jiang


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Abstract

This study explored FL-H2S, a novel fluorescein-based H2S donor, as an anti-inflammatory agent. The results demonstrated the efficient release of H2S by FL-H2S, along with its biocompatibility, real-time intracellular H2S release and imaging capability. In vivo experiments using a rat model confirmed the anti-inflammatory effects of FL-H2S, evidenced by reduced foot swelling. We also successfully elucidated the anti-inflammatory mechanism through ELISA and WB analysis.

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