Mitsunobu-initiated cascade cyclization of p-quinamines and 2-furanylmethanols: highly regio- and diastereoselective synthesis of functionalized hydrobenzo[c,d]indoles

Literature Information

Publication Date 2019-03-20
DOI 10.1039/C9OB00585D
Impact Factor 3.876
Authors

Bo Cao, Yin Wei


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Abstract

A cascade cyclization of para-quinamines and 2-furanylmethanol has been achieved, affording a series of functionalized hydrobenzo[c,d]indoles in moderate to good yields and excellent diastereoselectivities under mild conditions. This reaction was first initiated by the Mitsunobu reaction and then followed by the [4 + 2] Diels–Alder reaction to furnish the important indole-fused heterocyclic derivatives.

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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
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