![{3-[Bis(4-hydroxyphenyl)methyl]-1-[2-(dimethylamino)ethyl]-1H-indol-2-yl}[4-(2-chlorophenyl)-1-piperazinyl]methanone structure](https://static.chemtradehub.com/structs/170/170365-25-0-e4d7.webp "{3-[Bis(4-hydroxyphenyl)methyl]-1-[2-(dimethylamino)ethyl]-1H-indol-2-yl}[4-(2-chlorophenyl)-1-piperazinyl]methanone structure")
{3-[Bis(4-hydroxyphenyl)methyl]-1-[2-(dimethylamino)ethyl]-1H-indol-2-yl}[4-(2-chlorophenyl)-1-piperazinyl]methanone
CAS Number:
170365-25-0
Molecular Formula:
C36H37ClN4O3
Ruthenium(ii)-catalyzed [5 + 1] annulation reaction: a facile and efficient approach to construct 6-ethenyl phenanthridines utilizing a primary amine as a directing group
Literature Information
Publication Date
2020-09-01
DOI
10.1039/D0QO00769B
Impact Factor
5.281
Authors
Jian Chen, Baolan Tang, Xuexin Liu, Guanghui Lv, Yuesen Shi, Tianle Huang, Huimin Xing, Xiaoyu Guo, Li Hai, Yong Wu
View Original
Abstract
A ruthenium(II)-catalyzed [5 + 1] annulation reaction between 2-arylanilines and cyclopropenones employing a free amine as a directing group has been developed. This protocol provides a facile and practical method for the preparation of a variety of biologically valuable 6-ethenyl phenanthridine scaffolds, and features the use of the cost-effective ruthenium catalyst, good functional group tolerance and no requirement of an external oxidant.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
(S)-(1,4-Dioxan-2-yl)methyl 4-methylbenzenesulfonate
CAS Number:
917882-64-5
Molecular Formula:
C12H16O5S
![Ethyl thieno[3,2-f]quinoline-2-carboxylate structure](https://static.chemtradehub.com/structs/299/29948-26-3-f62b.webp "Ethyl thieno[3,2-f]quinoline-2-carboxylate structure")
(1-(2-(Dimethylamino)ethyl)-1H-pyrazol-4-yl)boronic acid
CAS Number:
1086063-73-1
Molecular Formula:
C7H14BN3O2
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