Ring expansion and fused cyclization catalysis to construct indoloquinazolinones with functionalization
Literature Information
Ramlal Baidya, Prasenjit Das, Pintu Pratihar, Dilip K. Maiti
In this study, a straightforward, moisture insensitive, and regioselective FeIII–CuII/p-TSA–CuI catalyzed reaction is achieved from readily available isatin and 2-alkynylaniline to furnish diverse 12-benzoyl/benzyl/alkyl indolo[1,2-c]quinazolin-6(5H)-ones. This catalytic method includes C–C cleavage, multi bond forming ring expansion, fused-ring construction, broad substrate scope, gram-scale producibility, and high atom economy.
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