Direct intramolecular arylation of unactivated arenes: application to the synthesis of aporphine alkaloids

Literature Information

Publication Date 2004-10-25
DOI 10.1039/B410394G
Impact Factor 6.222
Authors

Marc Lafrance, Nicole Blaquière, Keith Fagnou


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Abstract

The direct intramolecular C–H arylation of unactivated arenes is a viable strategy for the synthesis of aporphine alkaloids. These reactions occur with 3 to 5 mol% catalyst and generate the aporphine skeleton in up to 99% yield.

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