Small molecule modulators of immune pattern recognition receptors
Literature Information
Publication Date
2023-10-23
DOI
10.1039/D3CB00096F
Impact Factor
0
Authors
Taku Tsukidate, Charles W. Hespen
View Original
Abstract
Pattern recognition receptors (PRRs) represent a re-emerging class of therapeutic targets for vaccine adjuvants, inflammatory diseases and cancer. In this review article, we summarize exciting developments in discovery and characterization of small molecule PRR modulators, focusing on Toll-like receptors (TLRs), NOD-like receptors (NLRs) and the cGAS-STING pathway. We also highlight PRRs that are currently lacking small molecule modulators and opportunities for chemical biology and therapeutic discovery.
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