A strategy for orthogonal deubiquitination using a bump-and-hole approach
Literature Information
Publication Date
2023-10-02
DOI
10.1039/D3CB00095H
Impact Factor
0
Authors
Takumi Suzuki, Yuki Utsugi, Satoshi Yamanaka, Hirotaka Takahashi, Tatsuya Sawasaki, Yusaku Miyamae
View Original
Abstract
We have successfully applied a bump-and-hole approach to establish orthogonal deubiquitination in which a ubiquitin substrate variant is specifically targeted by an engineered deubiquitinating enzyme (DUB). This makes it possibe to selectively observe and measure a single type of DUB activity in living cells.
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