Rhenium and base co-catalyzed [3 + 2] annulations of N–H ketimines and alkynes to access unprotected tertiary indenamines through C–H bond activation
Literature Information
Publication Date
2015-12-24
DOI
10.1039/C5QO00336A
Impact Factor
5.281
Authors
Xiqing Jin, Xiaoxu Yang, Yunhui Yang, Congyang Wang
View Original
Abstract
Herein, a rhenium-catalyzed [3 + 2] carbocyclization of N–H ketimines and alkynes through C–H bond activation to afford unprotected tertiary indenamines is described. Notably, the catalytic use of a cheap base, sodium carbonate, was demonstrated to be crucial to the success of this reaction. The protocol is also highlighted by a high atom-economy, a broad substrate scope, and excellent regioselectivity for unsymmetrical alkynes.
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Organic Chemistry Frontiers
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