A bioluminescent probe for NQO1 overexpressing cancer cell imaging in vitro and in vivo
Literature Information
Publication Date
2022-10-28
DOI
10.1039/D2AN01435A
Impact Factor
4.616
Authors
Yuhong Luo, Wentao Wang, Yi Zeng, Shuangqing Wang, Xudong Guo, Rui Hu, Guoqiang Yang
View Original
Abstract
NAD(P)H quinone oxidoreductase1 (NQO1) is a flavoenzyme that regulates the redox potential level in cells. Overexpression of NQO1 has been proven to be relevant to some malignant tumors. Herein a bioluminescent probe NQO1-Luc equipped with an NQO1-targeting group, trimethyl-locked quinone propionic acid (QPA), was constructed. The reduction of NQO1-Luc could be triggered by NQO1, resulting in the release of free D-luciferin, and concomitantly a bright bioluminescence emission. NQO1-Luc exhibits high selectivity and sensitivity toward NQO1 activity and the capability of distinguishing NQO1-overexpressing cells in vitro and in vivo, which offers a promising tool for investigations of NQO1 related biological processes including tumors in living organisms.
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Source Journal
Analyst
CiteScore:
7.8
Self-citation Rate:
5.6%
Articles per Year:
653
Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
4-(Bromomethyl)-1-cyclohexyl-2-(trifluoromethyl)benzene
CAS Number:
800381-60-6
Molecular Formula:
C14H16BrF3
![6-(Benzyloxy)-8-(2-bromoacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one structure](https://static.chemtradehub.com/structs/926/926319-53-1-2287.webp "6-(Benzyloxy)-8-(2-bromoacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one structure")
6-(Benzyloxy)-8-(2-bromoacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
CAS Number:
926319-53-1
Molecular Formula:
C17H14BrNO4
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