Viscosity sensitive endoplasmic reticulum fluorescent probes based on oxazolopyridinium

Literature Information

Publication Date 2021-06-09
DOI 10.1039/D1TB01106E
Impact Factor 6.331
Authors

Ya-Nan Wang, Xiao-Qing Zhang, Ru Sun, Yu-Jie Xu, Jian-Feng Ge


View Original

Abstract

A series of viscosity sensitive fluorescent probes 1a–e were synthesized by linking coumarin and oxazolopyridinium via dimethylene in this paper. The viscosity test of probes 1a–e indicated that the fluorescence intensity of the probes enhanced significantly with the increase of viscosity of the system (0.89–865 cP), and exhibited a nearly OFF–ON response to viscosity at 648 nm, 650 nm and 650 nm, respectively. In addition, cells still had a high survival rate after co-culturing with probes 1a–e for 12 h (94–98%). Meanwhile, the laser confocal experiment showed that the variation of the carbon chain length in the oxazolopyridinium could affect the subcellular region of the localization of the probes in cells. When the length of the carbon chain in oxazolopyridinium was between n-C7H15 and n-C12H23, probes 1b–d had the ability to target the endoplasmic reticulum in the cells. Moreover, probes 1b–d showed no significant change in fluorescence intensity after 35 min of continuous laser confocal irradiation, indicating that they had excellent anti-photobleaching properties.

Related Literature

Exciplex formation between pyrene and guanine in highly polar solvents

Takahiro Kawai, Masashi Ikegami, Tatsuo Arai

2004-02-24 Communication

DOI: 10.1039/B316315F

Peptide-coated CdS quantum dots for the optical detection of copper(ii) and silver(i)‡

Kerim M. Gattás-Asfura, Roger M. Leblanc

2003-09-25 Communication

DOI: 10.1039/B308991F

A novel molecular ladder structure of Cu(ii)–Ba(ii) coordination polymer exhibiting ferromagnetic coupling

Yang Zou, Wenlong Liu, Song Gao, Jingli Xie, Qingjin Meng

2003-10-17 Communication

DOI: 10.1039/B308474D

On the relative migratory aptitudes of carbon and heteroatoms in borate complexes. A surprising α-thia effect

Jonathan M. Stoddard, Kenneth J. Shea

2004-02-27 Communication

DOI: 10.1039/B311292F

Different thermal reactivity of a 1,2-thiaphospholo[a]phosphirane in free and metal carbonyl complexed form

Tamaki Jikyo, Gerhard Maas

2003-10-14 Communication

DOI: 10.1039/B310256D

Rotavap simulation and the estimation of boiling points

Craig R. Stewart, Jonathan M. Goodman

2003-09-29 Communication

DOI: 10.1039/B309488J

Magnetic bead-based label-free chemiluminescence detection of telomeres

Jianzhong Lu, Choiwan Lau, Masaaki Kai

2003-10-20 Communication

DOI: 10.1039/B306895A

Applying reversible chemistry of CO2 to supramolecular polymers

Heng Xu, Erin M. Hampe, Dmitry M. Rudkevich

2003-10-14 Communication

DOI: 10.1039/B309580K

On-chip separation of peptides prepared within a micro reactor

Vinod George, Paul Watts, Stephen J. Haswell, Esteban Pombo-Villar

2003-10-22 Communication

DOI: 10.1039/B310744B

You might also like

Compound Q&A

What is the market or research trend for N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0)?

N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0) is increasingly being used ...

52818-63-0N-(4-Methoxybenzyl)-...
Compound Q&A

What precautions should be taken when handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate (CAS: 1050507-06-6)?

When handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate, appropriate p...

1050507-06-6Ethyl 4-(2-chlorophe...
Compound Q&A

What regulatory guidelines apply to diethyldiselane (CAS: 628-39-7)?

Diethyldiselane (CAS: 628-39-7) is classified under the Globally Harmonized Syst...

628-39-7Diethyldiselane
Compound Q&A

What is the market or research trend for oxocopper (CAS: 12053-18-8)?

The market for oxocopper (CAS: 12053-18-8) is primarily driven by its use in cat...

12053-18-8oxocopper; oxo-(oxoc...
Compound Q&A

What is the market or research trend for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-carboxylic acid?

The market for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-c...

1268519-54-55-{[(2-Methyl-2-prop...
Compound Q&A

What is 2-(1-Pyrrolidinyl)-4-pyridinamine (CAS: 35981-63-6)?

2-(1-Pyrrolidinyl)-4-pyridinamine is a chemical compound with the CAS number 359...

35981-63-62-(1-Pyrrolidinyl)-4...
Compound Q&A

What are the physical and chemical properties of 2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1)?

2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1) is a crystalline sol...

91556-75-12-(3-Pyridinyl)-1-az...
Compound Q&A

How is (S)-Alpha-allyl-proline hydrochloride (CAS: 129704-91-2) typically synthesized?

(S)-Alpha-allyl-proline hydrochloride is usually synthesized via a Wittig reacti...

129704-91-2(S)-Alpha-allyl-prol...
Compound Q&A

What is 3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5)?

3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5) is an organic compound w...

4857-42-53-Methyl-1,2-oxazole...
Compound Q&A

How is Lys-SMCC-DM1 (CAS: 1281816-04-3) typically synthesized?

Lys-SMCC-DM1 is synthesized via a multi-step process involving the coupling of S...

1281816-04-3Lys-SMCC-DM1

Source Journal

Journal of Materials Chemistry B

Journal of Materials Chemistry B
CiteScore: 12
Self-citation Rate: 4.9%
Articles per Year: 831

Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. The journals have a strong history of publishing quality reports of interest to interdisciplinary communities and providing an efficient and rigorous service through peer review and publication. The journals are led by an international team of Editors-in-Chief and Associate Editors who are all active researchers in their fields. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C. More than one Journal of Materials Chemistry journal may be suitable for certain fields and researchers are encouraged to submit their paper to the journal that they feel best fits for their particular article. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive. Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices image block All articles published in Journal of Materials Chemistry B from 2019 onwards will be indexed in MEDLINE®. Articles that primarily focus on providing insight into the underlying science and performance of biomaterials within a biological environment are more suited to our companion journal, Biomaterials Science.

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.