2-Pyridinylmethyl borrowing: base-promoted C-alkylation of (pyridin-2-yl)-methyl alcohols with ketones via cleavage of unstrained C(sp3)–C(sp3) bonds
Literature Information
Publication Date
2021-11-23
DOI
10.1039/D1QO01446C
Impact Factor
5.281
Authors
Chuan-Ming Hong, Fei-Fei Zou, Xin Zhuang, Zhen Luo, Zheng-Qiang Liu, Li-Qing Ren, Qing-Hua Li, Tang-Lin Liu
View Original
Abstract
A transition metal-free synthesis of β-(pyridin-2-yl)-methyl ketones, using (pyridin-2-yl)methyl alcohols and ketones through the 2-pyridinylmethyl borrowing strategy, has been disclosed. This approach provides an efficient, available and environmentally benign access, leading to alkylation products with broad functional group tolerance and excellent yields. Meanwhile, the selective cleavage of unactivated C(sp3)–C(sp3) bonds of common secondary alcohols was achieved with high atom economy.
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Organic Chemistry Frontiers
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