Palladium-catalyzed double carbonylation of propargyl amines and aryl halides to access 1-aroyl-3-aryl-1,5-dihydro-2H-pyrrol-2-ones
Literature Information
Publication Date
2020-03-24
DOI
10.1039/D0QO00007H
Impact Factor
5.281
Authors
Jun Ying, Zhengjie Le, Zhi-Peng Bao
View Original
Abstract
In this communication, we disclosed a palladium-catalyzed carbonylative procedure for the synthesis of 1-aroyl-3-aryl-1,5-dihydro-2H-pyrrol-2-ones from propargyl amines and aryl halides. By using TFBen as the CO source, the reaction provides a facile and straightforward access to various aryl-substituted 2-oxo-2,5-dihydropyrroles in good yields. The reaction mechanism is proven to be attractive as well.
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