Recent advances in organocatalytic asymmetric multicomponent cascade reactions for enantioselective synthesis of spirooxindoles
Literature Information
Publication Date
2021-05-07
DOI
10.1039/D1QO00220A
Impact Factor
5.281
Authors
Yongchao Wang, Angel A. Cobo, Annaliese K. Franz
View Original
Abstract
Asymmetric catalytic multicomponent cascade reactions have become indispensable tools for enantioselective construction of spirooxindoles. In recent years, a number of successful strategies have been developed for the synthesis of enantioenriched spirooxindoles in high yield with excellent stereo- and regioselectivity. This review summarizes the recent advances on enantioselective construction of spirooxindoles including spiro[N-heterocycle-oxindoles], spiro[cycloalkane-oxindoles] and spiro[O-heterocycle-oxindoles] catalyzed by chiral phosphoric acids, amines, and bifunctional thiourea/squaramides.
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Organic Chemistry Frontiers
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