Electrochemical α-methoxymethylation and aminomethylation of propiophenones using methanol as a green C1 source
Literature Information
Publication Date
2020-07-17
DOI
10.1039/D0QO00593B
Impact Factor
5.281
Authors
Xiu-Jin Meng, Yong-Zhou Pan, Shi-Kun Mo, Heng-Shan Wang, Hai-Tao Tang, Ying-Ming Pan
View Original
Abstract
Methanol plays a crucial role in organic synthesis as a green C1 source. Herein, the concise α-methoxymethylation and aminomethylation of propiophenones are achieved via electrochemical reactions with methanol as both the solvent and reactant. Methanol plays dual roles in this reaction: it is oxidized to formaldehyde (HCHO) and functions as a nucleophile. This protocol was performed under oxidant- and transition metal-free conditions.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
(1-(2-(Dimethylamino)ethyl)-1H-pyrazol-4-yl)boronic acid
CAS Number:
1086063-73-1
Molecular Formula:
C7H14BN3O2
(2S,4R)-4-(3-Bromobenzyl)pyrrolidine-2-carboxylic acid hydrochloride
CAS Number:
1049734-10-2
Molecular Formula:
C12H15BrClNO2
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