Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers
Literature Information
Publication Date
2020-11-19
DOI
10.1039/D0MD00284D
Impact Factor
0
Authors
Zoë Rachael Goddard, Andrew Michael Beekman, Marco M. D. Cominetti, Maria A. O'Connell, Isabelle Chambrier, Michael J. Cook, María J. Marín, David A. Russell, Mark Searcey
View Original
Abstract
Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.
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