Recent advances in synthetic and medicinal chemistry of phosphotyrosine and phosphonate-based phosphotyrosine analogues

Literature Information

Publication Date 2020-10-15
DOI 10.1039/D0MD00272K
Impact Factor 0
Authors

Nikolai Makukhin, Alessio Ciulli


View Original

Abstract

Phosphotyrosine-containing compounds attract significant attention due to their potential to modulate signalling pathways by binding to phospho-writers, erasers and readers such as SH2 and PTB domain containing proteins. Phosphotyrosine derivatives provide useful chemical tools to study protein phosphorylation/dephosphorylation, and as such represent attractive starting points for the development of binding ligands and chemical probes to study biology, and for inhibitor and degrader drug design. To overcome enzymatic lability of the phosphate group, physiologically stable phosphonate-based phosphotyrosine analogues find utility in a wide range of applications. This review covers advances over the last decade in the design of phosphotyrosine and its phosphonate-based derivatives, highlights the improved and expanded synthetic toolbox, and illustrates applications in medicinal chemistry.

Related Literature

Interplay between aggregation number, micelle charge and hydration of catanionic surfactants

Žiga Medoš, Sergej Friesen, Richard Buchner, Marija Bešter-Rogač

2020-04-17 Paper

DOI: 10.1039/D0CP00877J

Can glycine betaine denature proteins?

Arusha Acharyya, Dayoung Shin, Thomas Troxler, Feng Gai

2020-03-30 Paper

DOI: 10.1039/D0CP00397B

Phase separation in pore-spanning membranes induced by differences in surface adhesion

Jeremias Sibold, Vera E. Tewaag, Thomas Vagedes, Ingo Mey

2020-04-08 Paper

DOI: 10.1039/D0CP00335B

Role of hemibonding in the structure and ultraviolet spectroscopy of the aqueous hydroxyl radical

Bhaskar Rana, John M. Herbert

2020-11-12 Paper

DOI: 10.1039/D0CP05216G

Clarifying the impacts of surface hydroxyls on CO oxidation on CeO2(100) surfaces: a DFT+U study

Hui Zhou, Dong Wang, Xue-Qing Gong

2020-03-09 Paper

DOI: 10.1039/D0CP00204F

Yields of primary species in the low-linear energy transfer radiolysis of water in the temperature range of 25–700 °C

Abida Sultana, Jintana Meesungnoen, Jean-Paul Jay-Gerin

2020-03-18 Paper

DOI: 10.1039/D0CP00601G

High-performance III–VI monolayer transistors for flexible devices

Jianhui Chen, Shuchang Cai, Rui Xiong, Baisheng Sa, Cuilian Wen, Bo Wu, Zhimei Sun

2020-03-03 Paper

DOI: 10.1039/D0CP00578A

Microfluidic out-of-equilibrium control of molecular nanotubes

Björn Kriete, Carolien J. Feenstra, Maxim S. Pshenichnikov

2020-04-21 Paper

DOI: 10.1039/D0CP01734E

You might also like

155412-88-71-(3-Aminophenyl)-3-...
Compound Q&A

How should waste containing 1-(D-Ribofuranosyl)-1,4-dihydro-3-pyridinecarboxamide (CAS: 19132-12-8) be handled?

Waste containing 1-(D-Ribofuranosyl)-1,4-dihydro-3-pyridinecarboxamide (CAS: 191...

19132-12-81-(D-Ribofuranosyl)-...
Compound Q&A

What regulatory guidelines apply to 2-Methyl-2-propanyl 3-bromo-3-(hydroxymethyl)-1-azetidinecarboxylate (CAS: 2007919-81-3)?

2-Methyl-2-propanyl 3-bromo-3-(hydroxymethyl)-1-azetidinecarboxylate (CAS: 20079...

2007919-81-32-Methyl-2-propanyl ...
Compound Q&A

What is N-(4-Chloro-2-pyridinyl)acetamide (CAS: 245056-66-0)?

N-(4-Chloro-2-pyridinyl)acetamide (CAS: 245056-66-0) is a chemical compound with...

245056-66-0N-(4-Chloro-2-pyridi...
Compound Q&A

What is 5-Chloro-2-hydroxybenzoic acid (CAS: 321-14-2)?

5-Chloro-2-hydroxybenzoic acid, also known as 5-chlorosalicylic acid, is an arom...

321-14-25-Chloro-2-hydroxybe...
Compound Q&A

What precautions should be taken when handling 1,1-Dichloro-1-fluoroethane (CAS: 1717-00-6)?

When handling 1,1-Dichloro-1-fluoroethane (CAS: 1717-00-6), it is important to u...

1717-00-61,1-Dichloro-1-fluor...
Compound Q&A

What are the physical and chemical properties of Fmoc-(2S,3R)-3-phenylpyrrolidine-2-carboxylic acid (CAS: 281655-32-1)?

Fmoc-(2S,3R)-3-phenylpyrrolidine-2-carboxylic acid is a white crystalline solid ...

281655-32-1Fmoc-(2S,3R)-3-pheny...
Compound Q&A

What are the main uses of 4-Amino-5-bromo-2-pyridinecarboxylic acid (CAS: 1363381-01-4)?

4-Amino-5-bromo-2-pyridinecarboxylic acid is primarily used as a precursor in th...

1363381-01-44-Amino-5-bromo-2-py...
1007881-98-2(S)-tert-butyl 2-((2...
Compound Q&A

What precautions should be taken when handling 8-bromo-2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-3-one (CAS: 688363-73-7)?

When handling 8-bromo-2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-3-one, use prop...

688363-73-78-bromo-2,2-dimethyl...
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.