![N-[(9Z)-9-Octadecen-1-yl]-1,3-propanediamine structure](https://static.chemtradehub.com/structs/717/7173-62-8-d43e.webp "N-[(9Z)-9-Octadecen-1-yl]-1,3-propanediamine structure")
Rapid quantification of prion proteins using resistive pulse sensing
Literature Information
Publication Date
2020-02-12
DOI
10.1039/D0AN00063A
Impact Factor
4.616
Authors
Matthew J. Healey, Muttuswamy Sivakumaran, Mark Platt
View Original
Abstract
Prion diseases are a group of fatal transmissible neurological conditions caused by the change in conformation of intrinsic cellular prion protein (PrPC). We present a rapid assay using aptamers and resistive pulse sensing, RPS, to extract and quantify PrPC from complex sample matrices. We functionalise the surface of superparamagnetic beads, SPBs, with a DNA aptamer. First SPB's termed P-beads, are used to pre-concentrate the analyte from a large sample volume. The PrPC protein is then eluted from the P-beads before aptamer modified sensing beads, S-beads, are added. The velocity of the S-beads through the nanopore reveals the concentration of the PrPC protein. The process is done in under an hour and allows the detection of picomol's of protein.
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Analyst
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Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
![(2S)-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}(phenyl)acetic acid structure](https://static.chemtradehub.com/structs/102/102410-65-1-4aa7.webp "(2S)-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}(phenyl)acetic acid structure")
(2S)-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}(phenyl)acetic acid
CAS Number:
102410-65-1
Molecular Formula:
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