Transition-metal-free synthesis of CMe2CF3-containing chroman-4-ones via decarboxylative trifluoroalkylation
Literature Information
Publication Date
2019-12-12
DOI
10.1039/C9QO01283D
Impact Factor
5.281
Authors
Wei Liu, Hua-Yue Wu, Yun-Bing Zhou, Qiuping Ding, Yiyuan Peng
View Original
Abstract
(NH4)2S2O8-mediated decarboxylative trifluoroalkylation of alkenes with 3,3,3-trifluoro-2,2-dimethylpropanoic acid under metal-free conditions has been described. This approach provides a new pathway to directly synthesize a series of CMe2CF3-containing chroman-4-ones from simple chemical feedstocks. Particularly, the utility of the method was demonstrated by its application in the synthesis of CMe2CF3-derived TRPV1 precursors.
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Source Journal
Organic Chemistry Frontiers
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