![5-Bromoimidazo[1,2-a]pyridine structure](https://static.chemtradehub.com/structs/692/69214-09-1-d8e2.webp "5-Bromoimidazo[1,2-a]pyridine structure")
Efficient synthesis of tetrasubstituted 2,3-allenoates and preliminary studies on bioactivities
Literature Information
Publication Date
2018-12-11
DOI
10.1039/C8QO01202D
Impact Factor
5.281
Authors
Yuan Yao, Guirong Zhu, Qin Chen, Hui Qian
View Original
Abstract
A general and highly efficient straightforward protocol for the preparation of tetrasubstituted 2,3-allenoates through a palladium-catalyzed coupling reaction of 3-alkoxycarbonyl propargylic carbonates and boronic acids with commercially available tri(o-tolyl)phosphine as a ligand has been developed. This mild reaction exhibited a wide substrate scope and functional group compatibility, providing a highly efficient strategy to access valuable tetrasubstituted 2,3-allenoate products. Several tetrasubstituted 2,3-allenoates obtained in this study exhibited potent anti-cancer and anti-diabetic activities.
Related Literature
Femtosecond investigations on the ultrafast photo-dissociation dynamics of CpMn(CO)3 and its fragment ions
Cosmin Lupulescu, Štefan Vajda, Albrecht Lindinger, Andrea Merli, Ludger Wöste
2004-05-11
Paper
DOI: 10.1039/B402246G
Kinetics of electron–hole pair trapping via photoionization of biphenyl occluded in aluminium-rich ZSM-5 zeolites. Effects of extra-framework cations
Isabelle Gener, Alain Moissette, Claude Brémard
2004-05-10
Paper
DOI: 10.1039/B401816H
A site-selective spectroscopy of naphthalene and quinoline in TEOS/MTEOS xerogels
C. Crépin, V. Dubois, F. Goldfarb, F. Chaput, J. P. Boilot
2005-03-21
Paper
DOI: 10.1039/B500578G
Ti diffusion in La-doped SrTiO3 single crystals
Karsten Gömann, Günter Borchardt, Anissa Gunhold, Wolfgang Maus-Friedrichs, Horst Baumann
2004-04-02
Paper
DOI: 10.1039/B315210C
Solvent effect on the distance distribution between spin labels in aggregated spin labeled trichogin GA IV dimer peptides as studied by pulsed electron–electron double resonance
A. D. Milov, Yu. D. Tsvetkov, F. Formaggio, S. Oancea, C. Toniolo, J. Raap
2004-04-14
Paper
DOI: 10.1039/B313701E
Reactions of platinum clusters 195Ptn±, n = 1–24, with N2O studied with isotopically enriched platinum
Iulia Balteanu, O. Petru Balaj, Martin K. Beyer, Vladimir E. Bondybey
2004-05-04
Communication
DOI: 10.1039/B405211K
Indices for predicting the quality of leaving groups
Paul W. Ayers, James S. M. Anderson, Juan I. Rodriguez, Zobia Jawed
2005-04-05
Paper
DOI: 10.1039/B500996K
Molecular dynamics simulation of the squarate anion in acetonitrile solution
Ary O. Cavalcante, Sérgio M. Urahata, Mauro C. C. Ribeiro
2004-04-14
Paper
DOI: 10.1039/B402413C
Prediction of collective diffusion coefficient of bovine serum albumin in aqueous electrolyte solution with hard-core two-Yukawa potential
Yang-Xin Yu, Ai-Wei Tian, Guang-Hua Gao
2005-05-20
Paper
DOI: 10.1039/B500371G
Transitions and loci of solubilization of nutraceuticals in U-type nonionic microemulsions studied by self-diffusion NMR
Nissim Garti, Idit Amar-Yuli, Aviram Spernath, Roy E. Hoffman
2004-05-12
Paper
DOI: 10.1039/B404315B
You might also like
Compound Q&A
How should waste containing (6-Bromo-2-naphthyl)oxy](dimethyl)(2-methyl-2-propanyl)silane be handled?
Waste containing (6-Bromo-2-naphthyl)oxy](dimethyl)(2-methyl-2-propanyl)silane (...
100751-65-3[(6-Bromo-2-naphthyl...
Compound Q&A
How is 7-Fluoro-4-isoquinolinecarboxylic acid (CAS: 1841081-40-0) typically synthesized?
7-Fluoro-4-isoquinolinecarboxylic acid can be synthesized via a multi-step proce...
1841081-40-07-Fluoro-4-isoquinol...
Compound Q&A
What are the physical and chemical properties of 2,3,5,6-Tetrabromothieno[3,2-b]thiophene (CAS: 124638-53-5)?
2,3,5,6-Tetrabromothieno[3,2-b]thiophene is a crystalline compound with a high m...
124638-53-52,3,5,6-Tetrabromoth...
Compound Q&A
Is 1-[4-(Benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide (CAS: 1542705-92-9) safe?
1-[4-(Benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indol...
1542705-92-91-[4-(Benzylamino)-7...
Compound Q&A
What is the market or research trend for imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic acid, 3,4-dihydro-3-methyl-4-oxo- (CAS: 113942-30-6)?
The market for imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic acid, 3,4-dihydro-3...
113942-30-6Imidazo[5,1-d]-1,2,3...
Compound Q&A
What is 3-(Triisopropylsilyl)propiolaldehyde (CAS: 163271-80-5)?
3-(Triisopropylsilyl)propiolaldehyde is a synthetic organic compound with the CA...
163271-80-53-(Triisopropylsilyl...
Compound Q&A
What regulatory guidelines apply to 6-Nitro-2H-1,4-benzoxazin-3(4H)-one (CAS: 81721-87-1)?
6-Nitro-2H-1,4-benzoxazin-3(4H)-one (CAS: 81721-87-1) is subject to various regu...
81721-87-16-Nitro-2H-1,4-benzo...
Compound Q&A
How should waste containing (3-Fluorophenyl)(4-{[(2-methyl-2-propanyl)oxy]carbonyl}-1-piperazinyl)acetic acid (CAS: 885272-91-3) be handled?
Waste containing (3-Fluorophenyl)(4-{[(2-methyl-2-propanyl)oxy]carbonyl}-1-piper...
885272-91-3(3-Fluorophenyl)(4-{...
Compound Q&A
What are the physical and chemical properties of N,N'-4,4'-Biphenyldiyldiisonicotinamide (CAS: 55119-40-9)?
N,N'-4,4'-Biphenyldiyldiisonicotinamide is a white crystalline solid with a mole...
55119-40-9N,N'-4,4'-Biphenyldi...
Compound Q&A
What industries use 6-Bromo-8-fluoro-2-quinazolinol (CAS: 1036756-15-6)?
6-Bromo-8-fluoro-2-quinazolinol is primarily used in the pharmaceutical industry...
1036756-15-66-Bromo-8-fluoro-2-q...
Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
![(2S)-2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-4-pentynoic acid structure](https://static.chemtradehub.com/structs/630/63039-48-5-b66d.webp "(2S)-2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-4-pentynoic acid structure")
(2S)-2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-4-pentynoic acid
CAS Number:
63039-48-5
Molecular Formula:
C10H15NO4
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.