![trans-2-{[(Tert-butoxy)carbonyl]amino}cyclobutane-1-carboxylic acid structure](https://static.chemtradehub.com/structs/951/951173-25-4-27cd.webp "trans-2-{[(Tert-butoxy)carbonyl]amino}cyclobutane-1-carboxylic acid structure")
trans-2-{[(Tert-butoxy)carbonyl]amino}cyclobutane-1-carboxylic acid
CAS Number:
951173-25-4
Molecular Formula:
C10H17NO4
Transition metal-free aerobic oxidative cleavage of the C–N bonds of α-amino esters
Literature Information
Publication Date
2019-10-12
DOI
10.1039/C9QO01033E
Impact Factor
5.281
Authors
Shenpeng Tan, Feng Li, Soojun Park, Sanghee Kim
View Original
Abstract
An efficient transition metal-free cleavage of the C–N bonds of α-amino esters under mild conditions has been developed. The reaction was performed in the presence of KOtBu and molecular oxygen. Mechanistic studies reveal that the reaction proceeds through a base-mediated aerobic oxidative cleavage pathway involving the formation of a hydroperoxide intermediate.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
![(1R,6R)-6-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-3-cyclohexene-1-carboxylic acid structure](https://static.chemtradehub.com/structs/865/865689-24-3-5fef.webp "(1R,6R)-6-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-3-cyclohexene-1-carboxylic acid structure")
(1R,6R)-6-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-3-cyclohexene-1-carboxylic acid
CAS Number:
865689-24-3
Molecular Formula:
C12H19NO4
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