![3-[(3R,4R)-3-[(6-aminopyrimidin-4-yl)-methyl-amino]-4-methyl-1-piperidyl]-3-oxo-propanenitrile structure](https://static.chemtradehub.com/structs/164/1640971-60-3-83a4.webp "3-[(3R,4R)-3-[(6-aminopyrimidin-4-yl)-methyl-amino]-4-methyl-1-piperidyl]-3-oxo-propanenitrile structure")
3-[(3R,4R)-3-[(6-aminopyrimidin-4-yl)-methyl-amino]-4-methyl-1-piperidyl]-3-oxo-propanenitrile
CAS Number:
1640971-60-3
Molecular Formula:
C14H20N6O
Synthesis of tri-substituted allyl alcohols via a copper/iron co-catalyzed cascade perfluoroalkylation/rearrangement of aryl propynyl ethers
Literature Information
Publication Date
2019-09-05
DOI
10.1039/C9QO00848A
Impact Factor
5.281
Authors
Wei He, Jipan Yu, Dawei Wang, Guoxia Ran, Xiao-Feng Xia
View Original
Abstract
A copper/iron co-catalyzed fluoroalkylative cascade cyclization/1,4-aryl migration of aryl propynyl ethers with readily available iodoperfluoroalkane reagents for the synthesis of the corresponding perfluoroalkylated tri-substituted allyl alcohol derivatives is reported. This novel protocol provides a very mild method for the construction of perfluoroalkylated cinnamyl alcohols in one step with high regio- and stereo-selectivities. Further efficient application of this protocol is illustrated with the synthesis of 2-perfluoroalkyl-3-aryl-1H-indenes via a simple acidic workup.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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