Hybrid isoquinolines from Thalictrum foetidum: a new type of aporphine inhibiting Staphylococcus aureus by combined mechanisms
Literature Information
Publication Date
2019-08-29
DOI
10.1039/C9QO00737G
Impact Factor
5.281
Authors
Rong-Ping Zhang, Jing Yang, Xu-Jie Qin, Zhi Dai, Ya-Ping Liu, Qiu-Min Lu, Ren Lai
View Original
Abstract
Thalfoetines A–D (1–4), unique hybrid aporphine alkaloids with a C-7 aromatic unit formed by a new C–C bond linking two building blocks, were isolated from Thalictrum foetidum. Their structures were elucidated by extensive spectroscopic and computational analysis. They inhibited bacteria significantly, and compound 1 damaged the cell structure of Staphylococcus aureus and inhibited its DNA synthesis.
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Organic Chemistry Frontiers
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