Methyl 2-amino-4-(4-chlorophenyl)-5-pyrimidinecarboxylate
CAS Number:
1133115-56-6
Molecular Formula:
C12H10ClN3O2
Thiol substrate-promoted dehydrogenative cyclization of arylmethyl thiols with ortho-substituted amines: a universal approach to heteroaromatic compounds
Literature Information
Publication Date
2019-06-15
DOI
10.1039/C9QO00554D
Impact Factor
5.281
Authors
Mengjun Qiao, Ling Chen, Yibo Dong, Chengkang Jiao, Shengqi Liao
View Original
Abstract
A thiol substrate-promoted one-pot synthesis of a library of heteroaromatic compounds was developed. Benzo[d]oxazole, benzo[d]thiazole, benzo[d]imidazole, oxazolo[4,5-b]pyridine and naphtho[2,3-d]oxazole derivatives were obtained under metal-free and external oxidant-free conditions in moderate to excellent yields. Commercially available substrates and the absence of supplemental catalysts, oxidants or additives make this method both practical and efficient.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
![1H-Imidazo[4,5-c]pyridine-7-carboxylic acid structure](https://static.chemtradehub.com/structs/123/1234616-39-7-1344.webp "1H-Imidazo[4,5-c]pyridine-7-carboxylic acid structure")
4,4,5,5-Tetramethyl-2-(1-propyn-1-YL)-1,3,2-dioxaborolane
CAS Number:
347389-75-7
Molecular Formula:
C9H15BO2
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