Efficient and practical synthesis of unsymmetrical disulfides via base-catalyzed aerobic oxidative dehydrogenative coupling of thiols
Literature Information
Publication Date
2019-04-22
DOI
10.1039/C9QO00239A
Impact Factor
5.281
Authors
Xu Qiu, Xiaoxue Yang, Yiqun Zhang, Ning Jiao
View Original
Abstract
An efficient M2CO3-catalyzed (M = K or Cs) aerobic cross dehydrogenative coupling reaction of thiols was described. This reaction provided an efficient approach to unsymmetrical disulfides which are ubiquitous structures of pharmaceuticals and pesticides. This is the first aerobic oxidative CDC of thiols to unsymmetrical disulfides. The high atom-economy, easy accessibility of catalyst, O2 as the ideal green oxidant, mild reaction conditions, and broad substrate scope demonstrate that the present methodology provides a green, attractive, and practical approach to disulfides.
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Organic Chemistry Frontiers
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