Chitosan/rectorite nanocomposite with injectable functionality for skin hemostasis

Literature Information

Publication Date 2018-09-19
DOI 10.1039/C8TB01085D
Impact Factor 6.331
Authors

Xiaoyun Li, Yi-Chen Li, Mingjie Chen, Qingshan Shi, Runcang Sun, Xiaoying Wang


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Abstract

Many animals such as snails and Chinese giant salamanders can secrete mucus for moisturizing, eliminating swelling and inflammation, and promoting wound healing; this implies that high viscous bio-functional materials inspired by mucus may show potential for biomedical applications. Herein, we developed a maltose-like injectable nanocomposite via the combination of chitosan polysaccharide and clay rectorite for hemostasis. Through the hemostatic property of rectorite, the viscous nanocomposite decreased the in vitro clotting time by 43%. Moreover, an in vitro porcine skin model confirmed that the viscous nanocomposite can stably adhere on skin and impede blood bleeding successfully. Importantly, the internal structure of the nanocomposites, chitosan intercalating into rectorite interlayers, provided a physical cross-linked network to decrease the release of rectorite from the nanocomposite and its invasion into the blood. Therefore, this viscous injectable nanocomposite provided a concept for a facile and sustainable biomaterial for skin hemostasis.

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Journal of Materials Chemistry B

Journal of Materials Chemistry B
CiteScore: 12
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Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. The journals have a strong history of publishing quality reports of interest to interdisciplinary communities and providing an efficient and rigorous service through peer review and publication. The journals are led by an international team of Editors-in-Chief and Associate Editors who are all active researchers in their fields. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C. More than one Journal of Materials Chemistry journal may be suitable for certain fields and researchers are encouraged to submit their paper to the journal that they feel best fits for their particular article. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive. Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices image block All articles published in Journal of Materials Chemistry B from 2019 onwards will be indexed in MEDLINE®. Articles that primarily focus on providing insight into the underlying science and performance of biomaterials within a biological environment are more suited to our companion journal, Biomaterials Science.

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