Facile and practical synthesis of β-carbolinium salts and γ-carbolinium salts via rhodium-catalyzed three-component reactions

Literature Information

Publication Date 2018-06-20
DOI 10.1039/C8OB01182F
Impact Factor 3.876
Authors

Zhuo Wang, Tongyu Li, Siyang Xing, Bolin Zhu


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Abstract

A facile and practical [Cp*RhCl2]2-catalyzed three-component reaction between indolyl aldehydes, amines and alkynes involving C–H activation and cyclization has been developed. A series of β-carbolinium salts and γ-carbolinium salts are successfully afforded in good to quantitative yields under mild conditions. This efficient and convergent strategy provides a good choice for constructing the libraries of β-carbolinium salts and γ-carbolinium salts.

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Source Journal

Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
CiteScore: 3.4
Self-citation Rate: 10.3%
Articles per Year: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

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