Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS)
Literature Information
Publication Date
2018-04-09
DOI
10.1039/C8AN00258D
Impact Factor
4.616
Authors
L. M. Frensemeier, J. Mayr, G. Koellensperger, B. K. Keppler, C. R. Kowol, U. Karst
View Original
Abstract
Pt(IV) prodrugs are a class of promising anticancer agents, which are activated by reduction to the active Pt(II) species. Consequently, the reduction process is a crucial parameter. Herein, a new approach using electrochemistry (EC) coupled to liquid chromatography (LC) and electrospray ionization-mass spectrometry (ESI-MS) or inductively coupled plasma (ICP)-MS was applied. This enabled getting insights into the differences in the reduction and ligand release of platinum(IV) complexes with varying equatorial core structures.
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Analyst
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Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
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725746-35-0
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C13H13NO3
![N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-methionylglycine structure](https://static.chemtradehub.com/structs/234/23446-03-9-e1e5.webp "N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-methionylglycine structure")
N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-methionylglycine
CAS Number:
23446-03-9
Molecular Formula:
C12H22N2O5S
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