Ir/BiphPHOX-catalyzed asymmetric hydrogenation of 3-substituted 2,5-dihydropyrroles and 2,5-dihydrothiophene 1,1-dioxides

Literature Information

Publication Date 2017-05-11
DOI 10.1039/C7QO00248C
Impact Factor 5.281
Authors

Ke Meng, Jingzhao Xia, Yanzhao Wang, Xinghua Zhang, Guoqiang Yang


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Abstract

An efficient asymmetric hydrogenation of 3-substituted 2,5-dihydropyrroles using an Ir catalyst with an axially flexible chiral phosphine-oxazoline ligand was developed and chiral 3-substituted pyrrolidines could be prepared with excellent ee. 3-Substituted 2,5-dihydrothiophene 1,1-dioxides could also be hydrogenated by our catalyst, giving the desired products with moderate to high enantioselectivities.

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Organic Chemistry Frontiers

Organic Chemistry Frontiers
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