![4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl acetate structure](https://static.chemtradehub.com/structs/740/740081-22-5-f58f.webp "4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl acetate structure")
4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl acetate
CAS Number:
740081-22-5
Molecular Formula:
C17H13ClFN3O3
Synthesis of 3-((arylsulfonyl)methyl)indolin-2-ones via insertion of sulfur dioxide using anilines as the aryl source
Literature Information
Publication Date
2017-02-17
DOI
10.1039/C7QO00075H
Impact Factor
5.281
Authors
Tong Liu, Danqing Zheng
View Original
Abstract
Facile assembly of 3-((arylsulfonyl)methyl)indolin-2-ones via insertion of sulfur dioxide starting from anilines, N-arylacrylamides and DABCO·(SO2)2 is developed. This one-pot reaction proceeds efficiently in dichloroethane, leading to sulfonated oxindoles in good yields. Anilines serve as the aryl source, and the in situ generated sulfonyl radicals from sulfur dioxide as the key intermediates are trapped by N-arylacrylamides to provide the corresponding products. Additionally, a broad reaction scope is observed under mild conditions.
Related Literature
Triblock copolymers from lactide and telechelic poly(cyclohexene carbonate)
Michael R. Kember, James Copley, Antoine Buchard, Charlotte K. Williams
2012-03-02
Paper
DOI: 10.1039/C2PY00543C
Aromatic-aliphatic random and block copolyesters: synthesis, sequence distribution and thermal properties
Wen-Da Li, Jian-Bing Zeng, Xiao-Jie Lou, Jing-Jing Zhang, Yu-Zhong Wang
2012-03-26
Paper
DOI: 10.1039/C2PY20068F
Molecular imaging with polymers
Nathan R. B. Boase, Idriss Blakey, Kristofer J. Thurecht
2012-03-26
Minireview
DOI: 10.1039/C2PY20132A
Bioinspired dual self-folding of single polymer chains via reversible hydrogen bonding
Ozcan Altintas, Peter Gerstel
2011-11-11
Paper
DOI: 10.1039/C1PY00392E
Functional block copolymernanoparticles: toward the next generation of delivery vehicles
Maxwell J. Robb, Luke A. Connal, Bongjae F. Lee, Nathaniel A. Lynd
2012-04-18
Paper
DOI: 10.1039/C2PY20131C
Synthesis and water sorption of standard and end-capped polylactides: the effect of morphology
Donghun Koo, An Du, Giuseppe R. Palmese, Richard A. Cairncross
2012-01-04
Paper
DOI: 10.1039/C2PY00549B
Poly(dopamine acrylamide)-co-poly(propargyl acrylamide)-modified titanium surfaces for ‘click’ functionalization
Li Qun Xu, Hua Jiang, Koon-Gee Neoh, En-Tang Kang, Guo Dong Fu
2012-01-30
Paper
DOI: 10.1039/C2PY00552B
Rapidly thiol-responsive degradable block copolymer nanocarriers with facile bioconjugation
Samuel Aleksanian, Behnoush Khorsand, Rolf Schmidt, Jung Kwon Oh
2012-04-18
Paper
DOI: 10.1039/C2PY20154B
Carboxylic acids as latent initiators of radical polymerization carried out in the presence of hypervalent iodine compounds: synthesis of branched and transiently crosslinked polymers
Hongzhang Han, Nicolay V. Tsarevsky
2011-12-13
Paper
DOI: 10.1039/C1PY00495F
You might also like
Compound Q&A
Are there alternatives to 1-(4-Chlorophenyl)-N-hydroxymethanimine (CAS: 3848-36-0) in synthesis?
When considering alternatives to 1-(4-Chlorophenyl)-N-hydroxymethanimine (CAS: 3...
3848-36-01-(4-Chlorophenyl)-N...
Compound Q&A
How should (1R,9S,10S,12S,14E,16S,19R,20R,21S,22R)-3,9,21-Trihydroxy-5,10,12,14,16,20,22-heptamethyl-23,24-dioxatetracyclo[17.3.1.1~6,9~.0~2,7~]tetracosa-2,5,7,14-tetraen-4-one (CAS: 183202-73-5) be stored?
This compound should be stored in a cool, dry place away from direct sunlight. I...
183202-73-5(1R,9S,10S,12S,14E,1...
Compound Q&A
How is 3-(4-Bromophenyl)-5-(2-fluorophenyl)-1,2,4-oxadiazole (CAS: 419553-16-5) typically synthesized?
3-(4-Bromophenyl)-5-(2-fluorophenyl)-1,2,4-oxadiazole is synthesized through a m...
419553-16-53-(4-Bromophenyl)-5-...
Compound Q&A
How is 5-Chloro-2-(4-chlorophenyl)-4-methyl-6-[3-(1-piperidinyl)propoxy]pyrimidine (CAS: 1639220-19-1) typically synthesized?
5-Chloro-2-(4-chlorophenyl)-4-methyl-6-[3-(1-piperidinyl)propoxy]pyrimidine (CAS...
1639220-19-15-Chloro-2-(4-chloro...
Compound Q&A
What industries use 2-Chloro-4-(difluoromethoxy)pyridine (CAS: 1206978-15-5)?
2-Chloro-4-(difluoromethoxy)pyridine is used in the pharmaceutical industry for ...
1206978-15-52-Chloro-4-(difluoro...
Compound Q&A
What regulatory guidelines apply to 3-Chloro-6-methylpyridazine (CAS: 1121-79-5)?
3-Chloro-6-methylpyridazine (CAS: 1121-79-5) is classified under the Globally Ha...
1121-79-53-Chloro-6-methylpyr...
Compound Q&A
Are there alternatives to Methyl 4,5-dimethyl-2-nitrobenzoate in synthesis?
Several alternatives can be used in the synthesis of Methyl 4,5-dimethyl-2-nitro...
90922-74-0Methyl 4,5-dimethyl-...
Compound Q&A
Are there alternatives to (2E,2'E)-3,3'-(1,4-Phenylene)bisacrylaldehyde in synthesis?
Alternatives to (2E,2'E)-3,3'-(1,4-Phenylene)bisacrylaldehyde include other acry...
63405-68-5(2E,2'E)-3,3'-(1,4-P...
Compound Q&A
What is 3-Amino-5-chloropyridin-2-ol hydrochloride (CAS: 1261906-29-9)?
3-Amino-5-chloropyridin-2-ol hydrochloride is an organic compound with the CAS n...
1261906-29-93-Amino-5-chloropyri...
Compound Q&A
What precautions should be taken when handling 6,7-Difluoro-2,3-dihydro-4H-chromen-4-one (CAS: 1092349-93-3)?
When handling 6,7-Difluoro-2,3-dihydro-4H-chromen-4-one, it is essential to wear...
1092349-93-36,7-Difluoro-2,3-dih...
Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
(E)-2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-2-ol
CAS Number:
581802-26-8
Molecular Formula:
C11H21BO3
![6-Bromo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine structure](https://static.chemtradehub.com/structs/120/1203499-17-5-b4d1.webp "6-Bromo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine structure")
6-Bromo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine
CAS Number:
1203499-17-5
Molecular Formula:
C7H7BrN2O
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.