Recognition of chiral zwitterionic interactions at nanoscale interfaces by chiroplasmonic nanosensors

Literature Information

Publication Date 2017-06-01
DOI 10.1039/C7CP03004E
Impact Factor 3.676
Authors

Wenjing Zhao, Rong-Yao Wang, Hong Wei, Jingliang Li, Yinglu Ji, Xinxin Jiang, Xiaochun Wu, Xiangdong Zhang


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Abstract

The ability to detect chiral molecules renders plasmonic nanosensors as promising tools for the study of chirality phenomena in living systems. Using gold nanorod based plasmonic nanosensors, we investigated here typically chiral zwitterionic electrostatic (Zw-Es) and hydrogen-bonding (Hb) interactions occurring via amine and carboxylic groups at nanoscale interfaces in aqueous solutions. Our results reveal that the plasmonic circular dichroism responses of the nanosensors can have both conformational sensitivity and chiral selectivity to the interfacial molecular interactions. Such a dual function of the plasmonic nanosensors enables a new chiroptical way to differentiate between chiral Zw-Es and Hb interactions, to monitor the transformation between these two interaction forces, and particularly to recognize homochiral Zw-Es interactions in solution. Together with the surface enhanced Raman scattering (SERS) technique, this plasmonic CD based biosensing could have important values for the insightful understanding of chirality-dependent molecular recognition in biological and pharmaceutical systems.

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Source Journal

Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
Self-citation Rate: 10.3%
Articles per Year: 3036

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

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