Interactions of Hg(ii) with oligonucleotides having thymine–thymine mispairs. Optimization of an impedimetric Hg(ii) sensor
Literature Information
Ajar Kamal, Zhe She, Renu Sharma, Heinz-Bernhard Kraatz
The present work describes the effect of the number of thymine–thymine mispairs in single strand DNA probes on Hg(II) interactions and further to develop a highly sensitive DNA based impedimetric sensor for Hg(II) detection. To achieve this goal, the influence of the number of T–T mispairs on the signal response prompted by DNA–Hg(II) binding interactions was examined on three designed DNA probes: 5′-OH-(CH2)6-S-S-(CH2)6-AGTCCACACGTTCCTTACGC-3′, 5′-OH-(CH2)6-S-S-(CH2)6-AGTCCACATTTTCCTTTTGC-3′, 5′-OH-(CH2)6-S-S-(CH2)6-AGTCCATTTTTTCCTTTTTT-3′ having 2T–T, 4T–T and 6T–T mispairs with identical length, respectively. This study revealed that the number of T–T mispairs plays a critical role in maximizing the signal intensity of DNA–Hg(II) binding interactions. Based on these results, DNA comprising maximum number of T–T mispairs was further utilized for construction of the Hg(II) sensor, which exhibited a linear correlation between the change in charge transfer resistance (ΔRCT) and the concentration of Hg(II) over the range of 1.0 × 10−5 M to 1.0 × 10−10 M with a lower detection limit of 3.2 × 10−11 M. The selectivity was tested against 12 different metal ions including Hg(II). The ΔRCT response from Hg(II) is 3 times higher than the nearest competitor Pb(II) and approximately 10 times than other ions. The potential application of such a robust and label-free DNA sensor was demonstrated by analyzing environmental samples collected from Lake Ontario.
Related Literature
Hydrogen and carbon monoxide generation from laser-induced graphitized nanodiamonds in water
Dong Myung Jang, Hyung Soon Im, Yoon Myung, Yong Jae Cho, Han Sung Kim, Seung Hyuk Back, Jeunghee Park, Eun Hee Cha, Minyung Lee
DOI: 10.1039/C3CP50769F
Laser directed lithography of asymmetric graphene ribbons on a polydimethylsiloxane trench structure
Yi Yang, Dan Xie, Tian-Ling Ren, Yi Shu, Hui Sun, Chang-Jian Zhou, Xuan Liu, Lu-Qi Tao, Jie Ge, Cang-Hai Zhang, Yuegang Zhang
DOI: 10.1039/C3CP50538C
Manipulating dynamics with chemical structure: probing vibrationally-enhanced tunnelling in photoexcited catechol
Jamie D. Young, Dave Townsend, Justyna M. Żurek, Martin J. Paterson, Gareth M. Roberts, Vasilios G. Stavros
DOI: 10.1039/C3CP51108A
Analysis of visible-light-active Sn(ii)–TiO2 photocatalysts
Venkata Bharat Ram Boppana, Feng Jiao, Dave Newby, Jr., Jude Laverock, Kevin E. Smith, Jean Claude Jumas, Greg Hutchings, Raul F. Lobo
DOI: 10.1039/C3CP44635B
Ab initio simulations of scanning-tunneling-microscope images with embedding techniques and application to C58-dimers on Au(111)
Alexei Bagrets
DOI: 10.1039/C3CP44286A
Thermodynamics of oligomer formation: implications for secondary organic aerosol formation and reactivity
Joseph W. DePalma, Andrew J. Horan, Wiley A. Hall IV, Murray V. Johnston
DOI: 10.1039/C3CP44586K
Photoelectrical properties and the electronic structure of Tl1−xIn1−xSnxSe2 (x = 0, 0.1, 0.2, 0.25) single crystalline alloys
G. E. Davydyuk, H. Kamarudin, G. L. Myronchuk, S. P. Danylchuk, A. O. Fedorchuk, L. V. Piskach, M. Yu. Mozolyuk, O. V. Parasyuk
DOI: 10.1039/C3CP50836F
Origin of electrolyte-dopant dependent sulfur poisoning of SOFC anodes
ZhenHua Zeng, Mårten E. Björketun, Sune Ebbesen, Mogens B. Mogensen, Jan Rossmeisl
DOI: 10.1039/C3CP51099A
Fast phase formation of double-filled p-type skutterudites by ball-milling and hot-pressing
Qing Jie, Hengzhi Wang, Weishu Liu, Hui Wang, Gang Chen, Zhifeng Ren
DOI: 10.1039/C3CP50327E
Effective bulk and surface temperatures of the catalyst bed of FT-IR cells used for in situ and operando studies
Haoguang Li, Mickael Rivallan, Frederic Thibault-Starzyk, Arnaud Travert
DOI: 10.1039/C3CP50442E
You might also like
What is the market or research trend for N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0)?
N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0) is increasingly being used ...
What precautions should be taken when handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate (CAS: 1050507-06-6)?
When handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate, appropriate p...
What regulatory guidelines apply to diethyldiselane (CAS: 628-39-7)?
Diethyldiselane (CAS: 628-39-7) is classified under the Globally Harmonized Syst...
What is the market or research trend for oxocopper (CAS: 12053-18-8)?
The market for oxocopper (CAS: 12053-18-8) is primarily driven by its use in cat...
What is the market or research trend for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-carboxylic acid?
The market for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-c...
What is 2-(1-Pyrrolidinyl)-4-pyridinamine (CAS: 35981-63-6)?
2-(1-Pyrrolidinyl)-4-pyridinamine is a chemical compound with the CAS number 359...
What are the physical and chemical properties of 2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1)?
2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1) is a crystalline sol...
How is (S)-Alpha-allyl-proline hydrochloride (CAS: 129704-91-2) typically synthesized?
(S)-Alpha-allyl-proline hydrochloride is usually synthesized via a Wittig reacti...
What is 3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5)?
3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5) is an organic compound w...
How is Lys-SMCC-DM1 (CAS: 1281816-04-3) typically synthesized?
Lys-SMCC-DM1 is synthesized via a multi-step process involving the coupling of S...
Source Journal
Analyst

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.











![(2R,6S)-6-[(Benzyloxy)methyl]-4-{[(2-methyl-2-propanyl)oxy]carbonyl}-2-morpholinecarboxylic acid structure (2R,6S)-6-[(Benzyloxy)methyl]-4-{[(2-methyl-2-propanyl)oxy]carbonyl}-2-morpholinecarboxylic acid structure](https://static.chemtradehub.com/structs/109/1093085-91-6-3382.webp)

![1,10-bis(3,5-dimethylphenyl)-12-hydroxy-4,5,6,7-tetrahydroiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocine 12-oxide structure 1,10-bis(3,5-dimethylphenyl)-12-hydroxy-4,5,6,7-tetrahydroiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocine 12-oxide structure](https://static.chemtradehub.com/structs/141/1412439-82-7-b9a9.webp)
![5'-Fluoro-[2,3'-biindolinylidene]-2',3-dione structure 5'-Fluoro-[2,3'-biindolinylidene]-2',3-dione structure](https://static.chemtradehub.com/structs/251/251903-00-1-9cb1.webp)