Improvement of the control over SARA ATRP of 2-(diisopropylamino)ethyl methacrylate by slow and continuous addition of sodium dithionite
Literature Information
Joana R. Góis, Dominik Konkolewic, Anatoliy V. Popov, Tamaz Guliashvili, Krzysztof Matyjaszewski, Arménio C. Serra, Jorge F. J. Coelho
The kinetics and detailed mechanism of SARA ATRP of 2-(diisopropylamino)ethyl methacrylate (DPA) were investigated. Supplemental activator and reducing agent (SARA) atom transfer radical polymerization (ATRP) using sodium dithionite (Na2S2O4) was used to create well controlled polymers of PDPA. The influence of the initiator, solvent, structure and concentration of the catalyst was studied, and the ratios of Na2S2O4 were adjusted to optimize the polymerization. Well controlled polymers required Na2S2O4 to be slowly and continuously fed to the reaction mixture, with 500 parts per million (ppm) of CuBr2 with tris(2-dimethyamino)amine (Me6TREN) as a ligand. The initial content of Na2S2O4 in the reaction mixture, the feeding rate and the Cu catalyst concentration were optimized to provide polymers with narrow molecular weight distribution (Mw/Mn < 1.15) at high monomer conversion (∼90%). Interestingly, the results revealed that when tris(2-pyridylmethyl)-amine (TPMA) was used as a ligand, the amount of copper required to achieve similar control of the polymerization could be decreased 5 times. This system was successfully extended to the polymerization of oligo(ethylene oxide) methyl ether methacrylate (OEOMA). The high conversion and preservation of the chain-end functionality allows the direct synthesis of POEOMA-b-PDPA block copolymers. The low catalyst concentrations and benign nature of Na2S2O4 make this SARA ATRP method attractive for the synthesis of well controlled water soluble polymers for biomedical applications.
Related Literature
A photoluminescence “switch-on” nanosensor composed of nitrogen and sulphur co-doped carbon dots and gold nanoparticles for discriminative detection of glutathione
Jizhou Li, Xinyue Rao, Feng Xiang, Jianjia Wei, Mengke Yuan, Zhongde Liu
DOI: 10.1039/C8AN00168E
Highly sensitive and specific electrochemical biosensor for microRNA-21 detection by coupling catalytic hairpin assembly with rolling circle amplification
Qing Li, Fanpeng Zeng, Nan Lyu, Jun Liang
DOI: 10.1039/C8AN00437D
Fabrication of paper-based analytical devices optimized by central composite design
Vahid Hamedpour, Riccardo Leardi, Koji Suzuki, Daniel Citterio
DOI: 10.1039/C8AN00332G
Simple preparation and highly selective detection of silver ions using an electrochemical sensor based on sulfur-doped graphene and a 3,3′,5,5′-tetramethylbenzidine composite modified electrode
Yuan Yu
DOI: 10.1039/C7AN02084H
Construction of an ultrasensitive electrochemiluminescent aptasensor for ractopamine detection
Huiwen Xiong, Jingwen Gao, Ying Wang, Ziyi Chen, Miao-Miao Chen, Xiuhua Zhang, Shengfu Wang
DOI: 10.1039/C9AN00183B
Non-inertial lift induced migration for label-free sorting of cells in a co-flowing aqueous two-phase system
S. Hazra, K. S. Jayaprakash, K. Pandian, A. Raj, S. K. Mitra, A. K. Sen
DOI: 10.1039/C8AN02267D
Retracted Article: Rhodium nanocubes and nanotripods for highly sensitive ultraviolet surface-enhanced Raman spectroscopy
Rupali Das, R. K. Soni
DOI: 10.1039/C8AN00341F
Noncompetitive homogeneous immunodetection of small molecules based on beta-glucuronidase complementation
Jiulong Su, Tetsuya Kitaguchi, Yuki Ohmuro-Matsuyama, Hiroshi Ueda
DOI: 10.1039/C8AN00074C
You might also like
What precautions should be taken when handling lithium chloride hydrate (1:1:1) (CAS: 16712-20-2)?
When handling lithium chloride hydrate (1:1:1) (CAS: 16712-20-2), it is importan...
Is 4-(4H-1,2,4-Triazol-4-yl)piperidine (CAS: 690261-92-8) safe?
4-(4H-1,2,4-Triazol-4-yl)piperidine is generally considered safe for use in phar...
How should waste containing 1,3-Thiazole-2-carboxamide (CAS: 16733-85-0) be handled?
Waste containing 1,3-Thiazole-2-carboxamide (CAS: 16733-85-0) should be collecte...
What regulatory guidelines apply to 5-(Difluoromethyl)-2-fluorobenzonitrile (CAS: 934175-58-3)?
5-(Difluoromethyl)-2-fluorobenzonitrile (CAS: 934175-58-3) is subject to regulat...
How is Methyl 3-acetamido-2-thiophenecarboxylate (CAS: 22288-79-5) typically synthesized?
Methyl 3-acetamido-2-thiophenecarboxylate can be synthesized by the reaction of ...
What is 4-Isoquinolinecarbonitrile (CAS: 34846-65-6)?
4-Isoquinolinecarbonitrile is a chemical compound with the CAS number 34846-65-6...
How should Methyl 1H-1,2,3-triazole-4-carboxylate (CAS: 877309-59-6) be stored?
Store Methyl 1H-1,2,3-triazole-4-carboxylate (CAS: 877309-59-6) in a cool, dry p...
What regulatory guidelines apply to 6-Bromo[1,3]thiazolo[5,4-b]pyridin-2-amine (CAS: 1160791-13-8)?
6-Bromo[1,3]thiazolo[5,4-b]pyridin-2-amine (CAS: 1160791-13-8) is subject to the...
Is (2S,3S)-2-Ammonio-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate (CAS: 23651-95-8) safe?
(2S,3S)-2-Ammonio-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate (CAS: 23651-95-8) ...
What are the physical and chemical properties of 7-bromo-3-methyl-3,4-dihydroquinazolin-4-one (CAS: 1293987-84-4)?
7-Bromo-3-methyl-3,4-dihydroquinazolin-4-one is a solid with a crystalline form....
Source Journal
Polymer Chemistry

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.













![2-{3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one hydrochloride (1:1) structure 2-{3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one hydrochloride (1:1) structure](https://static.chemtradehub.com/structs/253/25332-39-2-496e.webp)
