Selective detection and complete identification of triglycerides in cortical bone by high-resolution 1H MAS NMR spectroscopy

Literature Information

Publication Date 2016-06-29
DOI 10.1039/C6CP03506J
Impact Factor 3.676
Authors

Peizhi Zhu, Michael D. Morris


View Original

Abstract

Using 1H-based magic angle spinning solid-state NMR spectroscopy, we report an atomistic-level characterization of triglycerides in compact cortical bone. By suppressing contributions from immobile molecules present in bone, we show that a 1H-based constant-time uniform-sign cross-peak (CTUC) two-dimensional COSY-type experiment that correlates the chemical shifts of protons can selectively detect a mobile triglyceride layer as the main component of small lipid droplets embedded on the surface of collagen fibrils. High sensitivity and resolution afforded by this NMR approach could be potentially utilized to investigate the origin of triglycerides and their pathological roles associated with bone fractures, diseases, and aging.

Related Literature

Photovoltaic devices and characterization of a dodecyloxybenzothiadiazole-based copolymer

Purna P. Maharjan, Qiliang Chen, Lianjie Zhang, Olusegun Adebanjo, Nirmal Adhikari, Swaminathan Venkatesan, Prajwal Adhikary, Bjorn Vaagensmith, Qiquan Qiao

2013-03-14 Paper

DOI: 10.1039/C3CP51070K

Thermodynamics of oligomer formation: implications for secondary organic aerosol formation and reactivity

Joseph W. DePalma, Andrew J. Horan, Wiley A. Hall IV, Murray V. Johnston

2013-03-22 Paper

DOI: 10.1039/C3CP44586K

Low temperature synthesis of wurtzite zinc sulfide (ZnS) thin films by chemical spray pyrolysis

Xin Zeng, Stevin S. Pramana, Sudip K. Batabyal, Xiaodong Chen, K. B. Jinesh

2013-01-17 Communication

DOI: 10.1039/C3CP43470B

Back matter

Front/Back Matter

DOI: 10.1039/C3CP90053C

Manipulating dynamics with chemical structure: probing vibrationally-enhanced tunnelling in photoexcited catechol

Jamie D. Young, Dave Townsend, Justyna M. Żurek, Martin J. Paterson, Gareth M. Roberts, Vasilios G. Stavros

2013-03-22 Paper

DOI: 10.1039/C3CP51108A

Modeling CO2reduction on Pt(111)

Chuan Shi, Christopher P. O'Grady, Andrew A. Peterson, Heine A. Hansen

2013-03-19 Paper

DOI: 10.1039/C3CP50645B

Mesoscopic modelling of frustration in microemulsions

Magali Duvail, Jean-François Dufrêche, Lise Arleth, Thomas Zemb

2013-03-18 Paper

DOI: 10.1039/C3CP43981J

Modeling environment effects on spectroscopies through QM/classical models

Benedetta Mennucci

2013-01-08 Perspective

DOI: 10.1039/C3CP44417A

Temperature and time dependence on ZnS microstructure and phases obtained through hydrothermal decomposition of diethyldithiocarbamate complexes

Guilherme Oliveira Siqueira, Tulio Matencio, Herculano Vieira da Silva, Yara Gonçalves de Souza, José Domingos Ardisson, Geraldo Magela de Lima, Arilza de Oliveira Porto

2013-03-04 Paper

DOI: 10.1039/C3CP50549A

Switching kinetics of electrochemical metallization memory cells

Stephan Menzel, Stefan Tappertzhofen, Ilia Valov

2013-03-14 Paper

DOI: 10.1039/C3CP50738F

You might also like

Compound Q&A

What precautions should be taken when handling 4-(2-Furylmethyl)thiomorpholine 1,1-dioxide (CAS: 79206-94-3)?

When handling 4-(2-Furylmethyl)thiomorpholine 1,1-dioxide (CAS: 79206-94-3), it ...

79206-94-34-(2-Furylmethyl)thi...
Compound Q&A

What precautions should be taken when handling 4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide (CAS: 71320-77-9)?

When handling 4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide (CAS: 71320-77-9), it...

71320-77-94-Chloro-N-[2-(4-mor...
Compound Q&A

How should waste containing 2-[2-(2-Methoxyethoxy)ethoxy]ethyl 4-methylbenzenesulfonate (CAS: 62921-74-8) be handled?

Waste containing this compound (CAS: 62921-74-8) should be handled according to ...

62921-74-82-[2-(2-Methoxyethox...
Compound Q&A

How should waste containing (S)-Methyl 2-amino-3-cyclohexylpropanoate be handled?

Waste containing (S)-Methyl 2-amino-3-cyclohexylpropanoate should be collected i...

40056-18-6(S)-Methyl 2-amino-3...
166882-70-85-({4-[(2S,4R)-4-Hyd...
Compound Q&A

Are there alternatives to (2E)-3-(3,4-Dichlorophenyl)acrylic acid (CAS: 7312-27-8) in synthesis?

There are several alternatives to (2E)-3-(3,4-Dichlorophenyl)acrylic acid in syn...

7312-27-8(2E)-3-(3,4-Dichloro...
Compound Q&A

How should Ethyl 6-(2-nitrophenyl)imidazo[2,1-b][1,3]thiazole-3-carboxylate (CAS: 925437-84-9) be stored?

Ethyl 6-(2-nitrophenyl)imidazo[2,1-b][1,3]thiazole-3-carboxylate (CAS: 925437-84...

925437-84-9Ethyl 6-(2-nitrophen...
Compound Q&A

How should waste containing 2-(1,3-Thiazol-2-yl)ethanamine (CAS: 18453-07-1) be handled?

Waste containing 2-(1,3-Thiazol-2-yl)ethanamine (CAS: 18453-07-1) should be coll...

18453-07-12-(1,3-Thiazol-2-yl)...
Compound Q&A

How is Methyl 5-iodo-2-methylbenzoate (CAS: 103440-54-6) typically synthesized?

Methyl 5-iodo-2-methylbenzoate can be synthesized through the iodination of meth...

103440-54-6Methyl 5-iodo-2-meth...
Compound Q&A

How is 5-Chloro[1,2,4]triazolo[1,5-a]pyridine (CAS: 1427399-34-5) typically synthesized?

5-Chloro[1,2,4]triazolo[1,5-a]pyridine is commonly synthesized via the condensat...

1427399-34-55-Chloro[1,2,4]triaz...

Source Journal

Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
Self-citation Rate: 10.3%
Articles per Year: 3036

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.