Study of the binding mechanism between aptamer GO18-T-d and gonyautoxin 1/4 by molecular simulation

Literature Information

Publication Date 2016-04-13
DOI 10.1039/C6CP00777E
Impact Factor 3.676
Authors

Shunxiang Gao, Xin Zheng, Dejing Liu, Mingjuan Sun, Jiaxiang Qin, Hao Zhou, Lianghua Wang


View Original

Abstract

GTX1/4 can induce the formation of an antiparallel G-quadruplex structure in aptamer GO18-T-d and combine steadily in the groove at the top of the G-quadruplex structure. The complex structures and special induced fit mechanism between aptamer and small molecules provide a reference for aptamer development in molecular diagnostics and therapeutic application.

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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
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